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Target
Platelet-activating factor receptor
Ligand
BDBM50062101
Substrate
n/a
Meas. Tech.
ChEMBL_158347 (CHEMBL768491)
Ki
0.630000±n/a nM
Citation
 Curtin, ML; Davidsen, SK; Heyman, HR; Garland, RB; Sheppard, GS; Florjancic, AS; Xu, L; Carrera, GM; Steinman, DH; Trautmann, JA; Albert, DH; Magoc, TJ; Tapang, P; Rhein, DA; Conway, RG; Luo, G; Denissen, JF; Marsh, KC; Morgan, DW; Summers, JB Discovery and evaluation of a series of 3-acylindole imidazopyridine platelet-activating factor antagonists. J Med Chem 41:74-95 (1998) [PubMed]  Article 
Target
Name:
Platelet-activating factor receptor
Synonyms:
PAF-R | PTAFR | PTAFR_CAVPO | Platelet activating factor receptor | Platelet-activating factor receptor
Type:
Protein
Mol. Mass.:
39005.63
Organism:
Cavia porcellus
Description:
n/a
Residue:
342
Sequence:
MELNSSSRVDSEFRYTLFPIVYSIIFVLGIIANGYVLWVFARLYPSKKLNEIKIFMVNLTVADLLFLITLPLWIVYYSNQGNWFLPKFLCNLAGCLFFINTYCSVAFLGVITYNRFQAVKYPIKTAQATTRKRGIALSLVIWVAIVAAASYFLVMDSTNVVSNKAGSGNITRCFEHYEKGSKPVLIIHICIVLGFFIVFLLILFCNLVIIHTLLRQPVKQQRNAEVRRRALWMVCTVLAVFVICFVPHHMVQLPWTLAELGMWPSSNHQAINDAHQVTLCLLSTNCVLDPVIYCFLTKKFRKHLSEKLNIMRSSQKCSRVTTDTGTEMAIPINHTPVNPIKN
  
Inhibitor
Name:
BDBM50062101
Synonyms:
4-Ethynyl-3-[3-fluoro-4-(2-methyl-imidazo[4,5-c]pyridin-1-ylmethyl)-benzoyl]-indole-1-carboxylic acid methylamide | CHEMBL433795
Type:
Small organic molecule
Emp. Form.:
C27H20FN5O2
Mol. Mass.:
465.4784
SMILES:
CNC(=O)n1cc(C(=O)c2ccc(Cn3c(C)nc4cnccc34)c(F)c2)c2c(cccc12)C#C
Structure:
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