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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50252739
Substrate
n/a
Meas. Tech.
ChEMBL_1837226 (CHEMBL4337359)
IC50
0.900000±n/a nM
Citation
Astolfi, A; Kudolo, M; Brea, J; Manni, G; Manfroni, G; Palazzotti, D; Sabatini, S; Cecchetti, F; Felicetti, T; Cannalire, R; Massari, S; Tabarrini, O; Loza, MI; Fallarino, F; Cecchetti, V; Laufer, SA; Barreca, ML Discovery of potent p38? MAPK inhibitors through a funnel like workflow combining in silico screening and in vitro validation. Eur J Med Chem 182:0 (2019) [PubMed] Article
More Info.:
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
Inhibitor
Name:
BDBM50252739
Synonyms:
CHEMBL494072 | N-Cyclopropyl-4-methyl-3-(2-((2-(4-morpholinyl)ethyl)amino)-6-quinazolinyl)benzamide | N-cyclopropyl-4-methyl-3-{2-[(2-morpholin-4-ylethyl)amino]quinazolin-6-yl}benzamide
Type:
Small organic molecule
Emp. Form.:
C25H29N5O2
Mol. Mass.:
431.5301
SMILES:
Cc1ccc(cc1-c1ccc2nc(NCCN3CCOCC3)ncc2c1)C(=O)NC1CC1