Reaction Details Report a problem with these data
Target
Mas-related G-protein coupled receptor member X1
Ligand
BDBM224021
Substrate
n/a
Meas. Tech.
ChEMBL_1837347 (CHEMBL4337480)
EC50
300±n/a nM
Citation
Prchalová, E; Hin, N; Thomas, AG; Veeravalli, V; Ng, J; Alt, J; Rais, R; Rojas, C; Li, Z; Hihara, H; Aoki, M; Yoshizawa, K; Nishioka, T; Suzuki, S; Kopajtic, T; Chatrath, S; Liu, Q; Dong, X; Slusher, BS; Tsukamoto, T Discovery of Benzamidine- and 1-Aminoisoquinoline-Based Human MAS-Related G-Protein-Coupled Receptor X1 (MRGPRX1) Agonists. J Med Chem 62:8631-8641 (2019) [PubMed] Article
More Info.:
Target
Name:
Mas-related G-protein coupled receptor member X1
Synonyms:
MRGX1_RAT | Mas-related G-protein coupled receptor member X1 | Mrgc | Mrgprc | Mrgprc11 | Mrgprx1 | Sensory neuron-specific G-protein coupled receptor 1 | Snsr | Snsr1
Type:
PROTEIN
Mol. Mass.:
37091.92
Organism:
Rattus norvegicus
Description:
ChEMBL_109489
Residue:
323
Sequence:
MDPTISSLSTESTTLNKTGHPSCRPILTLSFLVPIITLLGLAGNTIVLWLLGFRMRRKAISVYVLNLSLADSFFLCCHFIDSLMRIMNFYGIYAHKLSKEILGNAAIIPYISGLSILSAISTERCLSVLWPIWYHCHRPRNMSAIICVLIWVLSFLMGILDWFFSGFLGETHHHLWKNVDFIVTAFLIFLFMLLFGSSLALLVRILCGSRRKPLSRLYVTISLTVMVYLICGLPLGLYLFLLYWFGIHLHYPFCHIYQVTVLLSCVNSSANPIIYFLVGSFRHRKKHRSLKMVLKRALEETPEEDEYTDSHVQKPTEISERRC
Inhibitor
Name:
BDBM224021
Synonyms:
BAM8-22 | VGRPEWWMDYQKRYG
Type:
Small organic molecule
Emp. Form.:
C91H127N25O23S
Mol. Mass.:
1971.201
SMILES:
CSCC[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)CNC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)NCC(O)=O |r|