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Target
Cysteinyl leukotriene receptor 1
Ligand
BDBM50064069
Substrate
n/a
Meas. Tech.
ChEMBL_52208
Kd
1100±n/a nM
Citation
 Zwaagstra, ME; Timmerman, H; van de Stolpe, AC; de Kanter, FJ; Tamura, M; Wada, Y; Zhang, MQ Synthesis and structure-activity relationships of carboxyflavones as structurally rigid CysLT1 (LTD4) receptor antagonists. J Med Chem 41:1428-38 (1998) [PubMed]  Article  BDB Entry
Target
Name:
Cysteinyl leukotriene receptor 1
Synonyms:
n/a
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39007.58
Organism:
GUINEA PIG
Description:
Leukotriene D4 0 GUINEA PIG::Q2NNR5
Residue:
340
Sequence:
MDETGNPTIPPASNNTCYDSIDDFRNQVYSTLYSMISVVGFFGNGFVLYVLVKTYHEKSAFQVYMINLAVADLLCVCTLPLRVAYYVHKGIWLFGDFLCRLSTYALYVNLYCSIFFMTAMSFFRCVAIVFPVQNISLVTQKKARLVCIAIWMFVILTSSPFLMANTYKDEKNNTKCFEPPQDNQAKNYVLILHYVSLFIGFIIPFITIIVCYTMIIFTLLKSSMKKNLSSRKRAIGMIIVVTAAFLVSFMPYHIQRTIHLHFLHNKTKPCDSILRMQKSVVITLSLAASNCCFDPLLYFFSGGNFRRRLSTIRKYSLSSMTYIPKKKTSLPQKGKDICKE
  
Inhibitor
Name:
BDBM50064069
Synonyms:
4-Oxo-2-[4-(quinazolin-2-ylmethoxy)-phenyl]-4H-chromene-8-carboxylic acid | 4-oxo-2-(4-(quinazolin-2-ylmethoxy)phenyl)-4H-chromene-8-carboxylic acid | CHEMBL417135
Type:
Small organic molecule
Emp. Form.:
C25H16N2O5
Mol. Mass.:
424.4049
SMILES:
OC(=O)c1cccc2c1oc(cc2=O)-c1ccc(OCc2ncc3ccccc3n2)cc1
Structure:
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