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Target
Acid-sensing ion channel 1
Ligand
BDBM50000999
Substrate
n/a
Meas. Tech.
ChEMBL_1839999 (CHEMBL2090395)
IC50
56900±n/a nM
Citation
 Bencheva, LI; De Matteo, M; Ferrante, L; Ferrara, M; Prandi, A; Randazzo, P; Ronzoni, S; Sinisi, R; Seneci, P; Summa, V; Gallo, M; Veneziano, M; Cellucci, A; Mazzocchi, N; Menegon, A; Di Fabio, R Identification of Isoform 2 Acid-Sensing Ion Channel Inhibitors as Tool Compounds for Target Validation Studies in CNS. ACS Med Chem Lett 10:627-632 (2019) [PubMed]  Article  BDB Entry
Target
Name:
Acid-sensing ion channel 1
Synonyms:
ASIC1 | Accn2 | Acid-sensing ion channel | Acid-sensing ion channel 1 | Amiloride-sensitive cation channel 2, neuronal | Asic | BNaC2 | Brain sodium channel 2
Type:
PROTEIN
Mol. Mass.:
59657.36
Organism:
Mus musculus
Description:
ChEMBL_119368
Residue:
526
Sequence:
MELKTEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFCYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEACSAEDFKVVFTRYGKCYTFNSGQDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVSCQEQRLIYLPSPWGTCNAVTMDSDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHRLCRRGKCQKEAKRNSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC
  
Inhibitor
Name:
BDBM50000999
Synonyms:
CHEBI:81724 | DIMINAZENE
Type:
Small organic molecule
Emp. Form.:
C14H15N7
Mol. Mass.:
281.3158
SMILES:
NC(=N)c1ccc(N\N=N\c2ccc(cc2)C(N)=N)cc1
Structure:
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