Reaction Details Report a problem with these data
Target
Acid-sensing ion channel 2
Ligand
BDBM50510046
Substrate
n/a
Meas. Tech.
ChEMBL_1840001 (CHEMBL4340216)
IC50
>30000±n/a nM
Citation
 Bencheva, LI; De Matteo, M; Ferrante, L; Ferrara, M; Prandi, A; Randazzo, P; Ronzoni, S; Sinisi, R; Seneci, P; Summa, V; Gallo, M; Veneziano, M; Cellucci, A; Mazzocchi, N; Menegon, A; Di Fabio, R Identification of Isoform 2 Acid-Sensing Ion Channel Inhibitors as Tool Compounds for Target Validation Studies in CNS. ACS Med Chem Lett 10:627-632 (2019) [PubMed]  Article 
Target
Name:
Acid-sensing ion channel 2
Synonyms:
ASIC2_MOUSE | Accn1 | Acid-sensing ion channel 2 | Amiloride-sensitive brain sodium channel | Amiloride-sensitive cation channel 1, neuronal | Asic2 | BNC1 | Bnac1 | Brain sodium channel 1
Type:
PROTEIN
Mol. Mass.:
57721.82
Organism:
Mus musculus
Description:
ChEMBL_119368
Residue:
512
Sequence:
MDLKESPSEGSLQPSSIQIFANTSTLHGIRHIFVYGPLTIRRVLWAVAFVGSLGLLLVESSERVSYYFSYQHVTKVDEVVAQSLVFPAVTLCNLNGFRFSRLTTNDLYHAGELLALLDVNLQIPDPHLADPTVLEALRQKANFKHYKPKQFSMLEFLHRVGHDLKDMMLYCKFKGQECGHQDFTTVFTKYGKCYMFNSGEDGKPLLTTVKGGTGNGLEIMLDIQQDEYLPIWGETEETTFEAGVKVQIHSQSEPPFIQELGFGVAPGFQTFVATQEQRLTYLPPPWGECRSSEMGLDFFPVYSITACRIDCETRYIVENCNCRMVHMPGDAPFCTPEQHKECAEPALGLLAEKDSNYCLCRTPCNLTRYNKELSMVKIPSKTSAKYLEKKFNKSEKYISENILVLDIFFEALNYETIEQKKAYEVAALLGDIGGQMGLFIGASILTILELFDYIYELIKEKLLDLLGKEEEEGSHDENMSTCDTMPNHSETISHTVNVPLQTALGTLEEIAC
  
Inhibitor
Name:
BDBM50510046
Synonyms:
CHEMBL4440380
Type:
Small organic molecule
Emp. Form.:
C19H18FN3
Mol. Mass.:
307.3647
SMILES:
Cc1nn(c(C)c1-c1ccc(F)cc1)-c1ccc2CCNc2c1
Structure:
Search PDB for entries with ligand similarity: