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Target
Growth factor receptor-bound protein 2
Ligand
BDBM50064333
Substrate
n/a
Meas. Tech.
ChEMBL_72362 (CHEMBL686599)
IC50
0.004±n/a nM
Citation
 García-Echeverría, C; Furet, P; Gay, B; Fretz, H; Rahuel, J; Schoepfer, J; Caravatti, G Potent antagonists of the SH2 domain of Grb2: optimization of the X+1 position of 3-amino-Z-Tyr(PO3H2)-X+1-Asn-NH2. J Med Chem 41:1741-4 (1998) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50064333
Synonyms:
CHEMBL49860 | Phosphoric acid mono-(2-amino-4-{2-amino-2-[1-(1,2-dicarbamoyl-ethylcarbamoyl)-cyclohexylcarbamoyl]-ethyl}-phenyl) ester
Type:
Small organic molecule
Emp. Form.:
C20H31N6O8P
Mol. Mass.:
514.4693
SMILES:
NC(Cc1ccc(OP(O)(O)=O)c(N)c1)C(=O)NC1(CCCCC1)C(=O)NC(CC(N)=O)C(N)=O
Structure:
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