Target
Nuclear receptor ROR-gamma
Ligand
BDBM50510346
Substrate
n/a
Meas. Tech.
ChEMBL_1841432 (CHEMBL4341731)
IC50
116±n/a nM
Citation
 Tanis, VMVenkatesan, HCummings, MDAlbers, MKent Barbay, JHerman, KKummer, DAMilligan, CNelen, MINishimura, RSchlueter, TScott, BSpurlino, JWolin, RWoods, CXue, XEdwards, JPFourie, AMLeonard, K 3-Substituted Quinolines as ROR?t Inverse Agonists. Bioorg Med Chem Lett 29:1463-1470 (2019) [PubMed]  Article 
Target
Name:
Nuclear receptor ROR-gamma
Synonyms:
NR1F3 | Nuclear receptor ROR-gamma | Nuclear receptor ROR-gamma (RORC) | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C (RORc) | RORC | RORG | RORG_HUMAN | RZRG | Retinoid-related orphan receptor-gamma | Retinoid-related orphan receptor-gamma (RORc)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58218.40
Organism:
Homo sapiens (Human)
Description:
P51449
Residue:
518
Sequence:
MDRAPQRQHRASRELLAAKKTHTSQIEVIPCKICGDKSSGIHYGVITCEGCKGFFRRSQRCNAAYSCTRQQNCPIDRTSRNRCQHCRLQKCLALGMSRDAVKFGRMSKKQRDSLHAEVQKQLQQRQQQQQEPVVKTPPAGAQGADTLTYTLGLPDGQLPLGSSPDLPEASACPPGLLKASGSGPSYSNNLAKAGLNGASCHLEYSPERGKAEGRESFYSTGSQLTPDRCGLRFEEHRHPGLGELGQGPDSYGSPSFRSTPEAPYASLTEIEHLVQSVCKSYRETCQLRLEDLLRQRSNIFSREEVTGYQRKSMWEMWERCAHHLTEAIQYVVEFAKRLSGFMELCQNDQIVLLKAGAMEVVLVRMCRAYNADNRTVFFEGKYGGMELFRALGCSELISSIFDFSHSLSALHFSEDEIALYTALVLINAHRPGLQEKRKVEQLQYNLELAFHHHLCKTHRQSILAKLPPKGKLRSLCSQHVERLQIFQHLHPIVVQAAFPPLYKELFSTETESPVGLSK
  
Inhibitor
Name:
BDBM50510346
Synonyms:
CHEMBL4575356
Type:
Small organic molecule
Emp. Form.:
C28H32ClF3N6O2
Mol. Mass.:
577.041
SMILES:
COc1nc2ccc(cc2c(Cl)c1CN1CCC(CC1)C(F)(F)F)C(O)(c1cnc(C)n1C)c1cnc(C)n1C
Structure:
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