Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM50511362
Substrate
n/a
Meas. Tech.
ChEMBL_1844703 (CHEMBL4345130)
Ki
1.9±n/a nM
Citation
 Rajapaksa, NSGobbi, ADrobnick, JDo, SKolesnikov, ALiang, JChen, YSujatha-Bhaskar, SHuang, ZBrightbill, HFrancis, RYu, CChoo, EFDeMent, KRan, YAn, LEmson, CMaher, JWai, JMcKenzie, BSLupardus, PJZarrin, AAKiefer, JRBryan, MC Discovery of Potent Benzolactam IRAK4 Inhibitors with Robust in Vivo Activity. ACS Med Chem Lett 11:327-333 (2020) [PubMed]  Article 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM50511362
Synonyms:
CHEMBL4466981 | US10988478, Example 256
Type:
Small organic molecule
Emp. Form.:
C25H30N6O4
Mol. Mass.:
478.5435
SMILES:
COC(C)(C)CCN1Cc2cc(NC(=O)c3cnn4cccnc34)c(cc2C1=O)N1CCOCC1
Structure:
Search PDB for entries with ligand similarity: