Reaction Details Report a problem with these data
Target
Carbonic anhydrase 7
Ligand
BDBM50513291
Substrate
n/a
Meas. Tech.
ChEMBL_1852930 (CHEMBL4353554)
Ki
4.7±n/a nM
Citation
 Angeli, A; Di Cesare Mannelli, L; Ghelardini, C; Peat, TS; Bartolucci, G; Menicatti, M; Carta, F; Supuran, CT Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects. Eur J Med Chem 177:188-197 (2019) [PubMed]  Article 
Target
Name:
Carbonic anhydrase 7
Synonyms:
CA-VII | CA7 | CAH7_HUMAN | Carbonate dehydratase VII | Carbonic anhydrase | Carbonic anhydrase VII | Carbonic anhydrase VII (CA VII)
Type:
Enzyme
Mol. Mass.:
29664.11
Organism:
Homo sapiens (Human)
Description:
Human cloned isozyme.
Residue:
264
Sequence:
MTGHHGWGYGQDDGPSHWHKLYPIAQGDRQSPINIISSQAVYSPSLQPLELSYEACMSLSITNNGHSVQVDFNDSDDRTVVTGGPLEGPYRLKQFHFHWGKKHDVGSEHTVDGKSFPSELHLVHWNAKKYSTFGEAASAPDGLAVVGVFLETGDEHPSMNRLTDALYMVRFKGTKAQFSCFNPKCLLPASRHYWTYPGSLTTPPLSESVTWIVLREPICISERQMGKFRSLLFTSEDDERIHMVNNFRPPQPLKGRVVKASFRA
  
Inhibitor
Name:
BDBM50513291
Synonyms:
CHEMBL4448793
Type:
Small organic molecule
Emp. Form.:
C24H28N4O5SSe
Mol. Mass.:
563.53
SMILES:
[#6]-[#6]-1-[#6]-[#6]-[#6]C2([#6]-1)[#7]-[#6](=O)-[#7](-[#6]-[#6](=O)-[#7]-c1ccc([Se;v2][#6]-c3ccc(cc3)S([#7])(=O)=O)cc1)-[#6]2=O
Structure:
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