Reaction Details Report a problem with these data
Target
Glutamate receptor ionotropic, kainate 3
Ligand
BDBM50069111
Substrate
n/a
Meas. Tech.
ChEBML_89232
IC50
380±n/a nM
Citation
 Escribano, A; Ezquerra, J; Pedregal, C; Rubio, A; Yruretagoyena, B; Baker, SR; Wright, RA; Johnson, BG; Schoepp, DD (2S,4S)-amino-4-(2,2-diphenylethyl)pentanedioic acid selective group 2 metabotropic glutamate receptor antagonist. Bioorg Med Chem Lett 8:765-70 (1999) [PubMed]  Article 
Target
Name:
Glutamate receptor ionotropic, kainate 3
Synonyms:
Glutamate receptor ionotropic kainate 3 | GRIK3_RAT | Grik3 | Glur7 | Glutamate receptor ionotropic, kainate
Type:
PROTEIN
Mol. Mass.:
104080.46
Organism:
Rat
Description:
ChEMBL_1447329
Residue:
919
Sequence:
MTAPWRRLRSLVWEYWAGFLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQSLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNAHVSAIVEKWSMERLQAAPRAESGLLDGVMMTDAALLYDAVHIVSVCYQRASQMTVNSLQCHRHKPWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVAKGRGPNVTDSLTNRSLIVTTLLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRTLTADYALLMESTTIEYITQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFIYKLRKTAEREQRSFCSTVADEIRFSLTCQRRLKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMSCSTSLAPVFP
  
Inhibitor
Name:
BDBM50069111
Synonyms:
(2S,4S)-2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioic acid | 2-Amino-4-(2,2-diphenyl-ethyl)-pentanedioic acid | CHEMBL40123
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
N[C@@H](C[C@H](CC(c1ccccc1)c1ccccc1)C(O)=O)C(O)=O
Structure:
Search PDB for entries with ligand similarity: