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Target
Peroxisome proliferator-activated receptor delta
Ligand
BDBM50514827
Substrate
n/a
Meas. Tech.
ChEMBL_1858611 (CHEMBL4359340)
EC50
810±n/a nM
Citation
 Hanke, T; Cheung, SY; Kilu, W; Heering, J; Ni, X; Planz, V; Schierle, S; Faudone, G; Friedrich, M; Wanior, M; Werz, O; Windbergs, M; Proschak, E; Schubert-Zsilavecz, M; Chaikuad, A; Knapp, S; Merk, D A Selective Modulator of Peroxisome Proliferator-Activated Receptor ? with an Unprecedented Binding Mode. J Med Chem 63:4555-4561 (2020) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor delta
Synonyms:
NR1C2 | NUC1 | NUCI | Nuclear hormone receptor 1 | Nuclear receptor subfamily 1 group C member 2 | PPAR delta | PPAR-beta | PPARB | PPARD | PPARD_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor beta | Peroxisome proliferator-activated receptor delta
Type:
Enzyme
Mol. Mass.:
49910.45
Organism:
Homo sapiens (Human)
Description:
Q03181
Residue:
441
Sequence:
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY
  
Inhibitor
Name:
BDBM50514827
Synonyms:
CHEMBL4445084
Type:
Small organic molecule
Emp. Form.:
C21H22Cl2N2O4S3
Mol. Mass.:
533.511
SMILES:
CCCCCC[C@@H](Sc1nc2ccc(NS(=O)(=O)c3ccc(Cl)cc3Cl)cc2s1)C(O)=O |r|
Structure:
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