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Target
Interleukin-1 receptor-associated kinase 4
Ligand
BDBM50514942
Substrate
n/a
Meas. Tech.
ChEMBL_1859084 (CHEMBL4359940)
Ki
1.8±n/a nM
Citation
 Bryan, MC; Drobnick, J; Gobbi, A; Kolesnikov, A; Chen, Y; Rajapaksa, N; Ndubaku, C; Feng, J; Chang, W; Francis, R; Yu, C; Choo, EF; DeMent, K; Ran, Y; An, L; Emson, C; Huang, Z; Sujatha-Bhaskar, S; Brightbill, H; DiPasquale, A; Maher, J; Wai, J; McKenzie, BS; Lupardus, PJ; Zarrin, AA; Kiefer, JR Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors. J Med Chem 62:6223-6240 (2019) [PubMed]  Article 
Target
Name:
Interleukin-1 receptor-associated kinase 4
Synonyms:
IRAK-4 | IRAK4 | IRAK4_HUMAN | Interleukin-1 receptor-associated kinase 4 (IRAK-4) | Interleukin-1 receptor-associated kinase 4 (IRAK4) | Renal carcinoma antigen NY-REN-64
Type:
Protein
Mol. Mass.:
51519.08
Organism:
Homo sapiens (Human)
Description:
Q9NWZ3
Residue:
460
Sequence:
MNKPITPSTYVRCLNVGLIRKLSDFIDPQEGWKKLAVAIKKPSGDDRYNQFHIRRFEALLQTGKSPTSELLFDWGTTNCTVGDLVDLLIQNEFFAPASLLLPDAVPKTANTLPSKEAITVQQKQMPFCDKDRTLMTPVQNLEQSYMPPDSSSPENKSLEVSDTRFHSFSFYELKNVTNNFDERPISVGGNKMGEGGFGVVYKGYVNNTTVAVKKLAAMVDITTEELKQQFDQEIKVMAKCQHENLVELLGFSSDGDDLCLVYVYMPNGSLLDRLSCLDGTPPLSWHMRCKIAQGAANGINFLHENHHIHRDIKSANILLDEAFTAKISDFGLARASEKFAQTVMTSRIVGTTAYMAPEALRGEITPKSDIYSFGVVLLEIITGLPAVDEHREPQLLLDIKEEIEDEEKTIEDYIDKKMNDADSTSVEAMYSVASQCLHEKKNKRPDIKKVQQLLQEMTAS
  
Inhibitor
Name:
BDBM50514942
Synonyms:
CHEMBL4483477
Type:
Small organic molecule
Emp. Form.:
C25H30N8O3
Mol. Mass.:
490.5575
SMILES:
Cn1c(nc2cc(N3CCC(CO)CC3)c(NC(=O)c3cnn4cccnc34)cc12)N1CCOCC1
Structure:
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