Reaction Details Report a problem with these data
Target
Oxysterols receptor LXR-beta
Ligand
BDBM23448
Substrate
n/a
Meas. Tech.
ChEMBL_1859653 (CHEMBL4360509)
Ki
66000±n/a nM
Citation
 Zhang, Z; Chen, H; Chen, Z; Ding, P; Ju, Y; Gu, Q; Xu, J; Zhou, H Identify liver X receptor ? modulator building blocks by developing a fluorescence polarization-based competition assay. Eur J Med Chem 178:458-467 (2019) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM23448
Synonyms:
BUTYLPARABEN | Butyl paraben | Nipabutyl | butyl 4-hydroxybenzoate | cid_7184
Type:
Small organic molecule
Emp. Form.:
C11H14O3
Mol. Mass.:
194.2271
SMILES:
CCCCOC(=O)c1ccc(O)cc1
Structure:
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