Reaction Details
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S-adenosylmethionine synthase isoform type-1
Ligand
BDBM50070637
Substrate
n/a
Meas. Tech.
ChEBML_197501
Ki
56000±n/a nM
Citation
Lavrador, K; Guillerm, D; Guillerm, G A new series of cyclic amino acids as inhibitors of S-adenosyl L-methionine synthetase. Bioorg Med Chem Lett 8:1629-34 (1999) [PubMed] Article More Info.:
Target
Name:
S-adenosylmethionine synthase isoform type-1
Synonyms:
AdoMet synthetase 1 | Ams1 | MAT 1 | MAT-I/III | METK1_RAT | Mat1a | Methionine adenosyltransferase 1 | Methionine adenosyltransferase I/III | S-adenosylmethionine synthetase (MAT 1 and MAT 2) | S-adenosylmethionine synthetase alpha and beta forms | S-adenosylmethionine synthetase isoform type-1
Type:
PROTEIN
Mol. Mass.:
43692.87
Organism:
Rattus norvegicus
Description:
ChEMBL_11027
Residue:
397
Sequence:
MNGPVDGLCDHSLSEEGAFMFTSESVGEGHPDKICDQISDAVLDAHLKQDPNAKVACETVCKTGMVLLCGEITSMAMIDYQRVVRDTIKHIGYDDSAKGFDFKTCNVLVALEQQSPDIAQCVHLDRNEEDVGAGDQGLMFGYATDETEECMPLTIVLAHKLNTRMADLRRSGVLPWLRPDSKTQVTVQYVQDNGAVIPVRVHTIVISVQHNEDITLEAMREALKEQVIKAVVPAKYLDEDTIYHLQPSGRFVIGGPQGDAGVTGRKIIVDTYGGWGAHGGGAFSGKDYTKVDRSAAYAARWVAKSLVKAGLCRRVLVQVSYAIGVAEPLSISIFTYGTSKKTERDELLEVVNKNFDLRPGVIVRDLDLKKPIYQKTACYGHFGRSEFPWEVPKKLVF
Inhibitor
Name:
BDBM50070637
Synonyms:
CHEMBL295971 | L-2-amino-4-methoxy-cis-but-3-enoic acid
Type:
Small organic molecule
Emp. Form.:
C5H9NO3
Mol. Mass.:
131.1299
SMILES:
CO\C=C/[C@H](N)C(O)=O
Structure:
