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Target
Endothelin-1 receptor
Ligand
BDBM50516235
Substrate
n/a
Meas. Tech.
ChEMBL_1864039 (CHEMBL4365014)
EC50
>10000±n/a nM
Citation
 Amato, G; Manke, A; Wiethe, R; Vasukuttan, V; Snyder, R; Yueh, YL; Decker, A; Runyon, S; Maitra, R Functionalized 6-(Piperidin-1-yl)-8,9-Diphenyl Purines as Peripherally Restricted Inverse Agonists of the CB1 Receptor. J Med Chem 62:6330-6345 (2019) [PubMed]  Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
Endothelin receptor type A | ET-A | ETA-R | hET-AR | EDNRA_HUMAN | EDNRA | ETA | ETRA | Endothelin receptor, ET-A/ET-B
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48736.88
Organism:
Human
Description:
P25101
Residue:
427
Sequence:
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN
  
Inhibitor
Name:
BDBM50516235
Synonyms:
CHEMBL4563408
Type:
Small organic molecule
Emp. Form.:
C29H24Cl2F2N8O2
Mol. Mass.:
625.47
SMILES:
FC(F)Oc1ccc(NC(=O)NC2CCN(CC2)c2ncnc3n(c(nc23)-c2ccccc2Cl)-c2ccc(Cl)cc2)cn1
Structure:
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