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Target
Adenosine receptor A2a
Ligand
BDBM50085658
Substrate
n/a
Meas. Tech.
ChEMBL_1868860 (CHEMBL4369926)
Ki
988±n/a nM
Citation
 Tosh, DK; Rao, H; Bitant, A; Salmaso, V; Mannes, P; Lieberman, DI; Vaughan, KL; Mattison, JA; Rothwell, AC; Auchampach, JA; Ciancetta, A; Liu, N; Cui, Z; Gao, ZG; Reitman, ML; Gavrilova, O; Jacobson, KA Design and in Vivo Characterization of A J Med Chem 62:1502-1522 (2019) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
Adenosine receptor A2a | AA2AR_MOUSE | Adora2a | Adenosine A2a receptor
Type:
PROTEIN
Mol. Mass.:
44984.04
Organism:
Mouse
Description:
ChEMBL_479903
Residue:
410
Sequence:
MGSSVYIMVELAIAVLAILGNVLVCWAVWINSNLQNVTNFFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFFACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGMRAKGIIAICWVLSFAIGLTPMLGWNNCSQKDENSTKTCGEGRVTCLFEDVVPMNYMVYYNFFAFVLLPLLLMLAIYLRIFLAARRQLKQMESQPLPGERTRSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCSTCQHAPPWLMYLAIILSHSNSVVNPFIYAYRIREFRQTFRKIIRTHVLRRQEPFRAGGSSAWALAAHSTEGEQVSLRLNGHPLGVWANGSAPHSGRRPNGYTLGPGGGGSTQGSPGDVELLTQEHQEGQEHPGLGDHLAQGRVGTASWSSEFAPS
  
Inhibitor
Name:
BDBM50085658
Synonyms:
2-Cl-CPA | CHEMBL284969 | 2-chloro-N6-cyclopentyladenosine | (2R,3R,4S,5R)-2-(2-Chloro-6-cyclopentylamino-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol | 5-(2-Chloro-6-cyclopentylamino-purin-9-yl)-tetrahydro-furan-2,3,4-triol | (2R,3R,4S,5R)-2-(2-chloro-6-(cyclopentylamino)-9H-purin-9-yl)-5-(hydroxymethyl)-tetrahydrofuran-3,4-diol | CCPA | 2-(2-Chloro-6-cyclopentylamino-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol | N6-Cyclopentyl-2-chloroAdo | 2-(2-Chloro-6-cyclopentylamino-purin-9-yl)-5-hydroxymethyl-tetrahydro-furan-3,4-diol(CCPA)
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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