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Target
Short transient receptor potential channel 5
Ligand
BDBM49021
Substrate
n/a
Meas. Tech.
ChEMBL_1871622 (CHEMBL4372789)
IC50
4060±n/a nM
Citation
 Sharma, SH; Pablo, JL; Montesinos, MS; Greka, A; Hopkins, CR Design, synthesis and characterization of novel N-heterocyclic-1-benzyl-1H-benzo[d]imidazole-2-amines as selective TRPC5 inhibitors leading to the identification of the selective compound, AC1903. Bioorg Med Chem Lett 29:155-159 (2019) [PubMed]  Article 
Target
Name:
Short transient receptor potential channel 5
Synonyms:
CCE2 | Capacitative calcium entry channel 2 | Short transient receptor potential channel 5 | TRP-5 | TRPC5_MOUSE | Transient receptor protein 5 | Trp-related protein 5 | Trp5 | Trpc5 | Trrp5 | mTRP5
Type:
PROTEIN
Mol. Mass.:
111470.55
Organism:
Mus musculus
Description:
ChEMBL_119231
Residue:
975
Sequence:
MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLSAVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRKPSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRHNLRSFTERHADSLIQNQHYQEVIRNLVKRYVAAMIRNSKTNEGLTEENFKELKQDISSFRYEVLDLLGNRKHPRRSLSTSSADFSQRDDTNDGSGGARAKSKSVSFNVGCKKKACHGAPLIRTVPRASGAQGKPKSESSSKRSFMGPSFKKLGLFFSKFNGQTSEPTSEPMYTISDGIAQQHCMWQDIRYSQMEKGKAEACSQSQMNLGEVELGEIRGAAARSSECPLACSSSLHCASGICSSNSKLLDSSEDVFETWGEACDLLMHKWGDGQEEQVTTRL
  
Inhibitor
Name:
BDBM49021
Synonyms:
(1-benzylbenzimidazol-2-yl)-(2-furfuryl)amine | 1-benzyl-N-(furan-2-ylmethyl)benzimidazol-2-amine | MLS000084083 | N-(2-furanylmethyl)-1-(phenylmethyl)-2-benzimidazolamine | N-(furan-2-ylmethyl)-1-(phenylmethyl)benzimidazol-2-amine | SMR000048469 | cid_667146
Type:
Small organic molecule
Emp. Form.:
C19H17N3O
Mol. Mass.:
303.3578
SMILES:
C(Nc1nc2ccccc2n1Cc1ccccc1)c1ccco1
Structure:
Search PDB for entries with ligand similarity: