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Target
Serine/threonine-protein kinase pim-1/pim-2/pim-3
Ligand
BDBM50518504
Substrate
n/a
Meas. Tech.
ChEMBL_1871839 (CHEMBL4373006)
EC50
70±n/a nM
Citation
 Barberis, C; Pribish, J; Tserlin, E; Gross, A; Czekaj, M; Barragué, M; Erdman, P; Maniar, S; Jiang, J; Fire, L; Patel, V; Hebert, A; Levit, M; Wang, A; Sun, F; Huang, SA Discovery of N-substituted 7-azaindoles as Pan-PIM kinases inhibitors - Lead optimization - Part III. Bioorg Med Chem Lett 29:491-495 (2019) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase pim-1/pim-2/pim-3
Synonyms:
Serine/threonine-protein kinase PIM
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 2135988
Components:
This complex has 3 components.
Component 1
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
Serine/threonine-protein kinase PIM | PIM-1 Kinase | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1) | PIM1_HUMAN | PIM1
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Human
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Component 2
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase pim-2 (PIM2) | PIM2_HUMAN | PIM2 | Serine/threonine-protein kinase PIM
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Human
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
  
Component 3
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
Serine/threonine-protein kinase pim-3 (PIM3) | PIM3_HUMAN | PIM3
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Human
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM50518504
Synonyms:
CHEMBL4466764
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: