Target
Growth factor receptor-bound protein 2
Ligand
BDBM50072869
Substrate
n/a
Meas. Tech.
ChEMBL_72185 (CHEMBL680003)
IC50
11±n/a nM
Citation
 Yao, ZJKing, CRCao, TKelley, JMilne, GWVoigt, JHBurke, TR Potent inhibition of Grb2 SH2 domain binding by non-phosphate-containing ligands. J Med Chem 42:25-35 (1999) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50072869
Synonyms:
CHEMBL331463 | Phosphoric acid mono-{4-[(S)-2-acetylamino-2-(1-{(S)-2-carbamoyl-1-[3-(2-hydroxy-naphthalen-1-yl)-propylcarbamoyl]-ethylcarbamoyl}-cyclohexylcarbamoyl)-ethyl]-phenyl} ester
Type:
Small organic molecule
Emp. Form.:
C35H44N5O10P
Mol. Mass.:
725.7251
SMILES:
CC(=O)N[C@@H](Cc1ccc(OP(O)(O)=O)cc1)C(=O)NC1(CCCCC1)C(=O)N[C@@H](CC(N)=O)C(=O)NCCCc1c(O)ccc2ccccc12
Structure:
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