Target
Muscarinic acetylcholine receptor M4
Ligand
BDBM50518719
Substrate
n/a
Meas. Tech.
ChEMBL_1872177 (CHEMBL4373344)
EC50
2100±n/a nM
Citation
 Poslusney, MSSalovich, JMWood, MRMelancon, BJBollinger, KALuscombe, VBRodriguez, ALEngers, DWBridges, TMNiswender, CMConn, PJLindsley, CW Novel M Bioorg Med Chem Lett 29:362-366 (2019) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M4
Synonyms:
ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
53079.31
Organism:
Homo sapiens (Human)
Description:
Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173
Residue:
479
Sequence:
MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
  
Inhibitor
Name:
BDBM50518719
Synonyms:
CHEMBL4467950
Type:
Small organic molecule
Emp. Form.:
C20H20N2O3S
Mol. Mass.:
368.449
SMILES:
Cc1c(sc2nc(C)cc(C)c12)C(=O)NCc1ccc2OCCOc2c1
Structure:
Search PDB for entries with ligand similarity: