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Target
Muscarinic acetylcholine receptor M4
Ligand
BDBM50518731
Substrate
n/a
Meas. Tech.
ChEMBL_1872177 (CHEMBL4373344)
EC50
3800±n/a nM
Citation
 Poslusney, MS; Salovich, JM; Wood, MR; Melancon, BJ; Bollinger, KA; Luscombe, VB; Rodriguez, AL; Engers, DW; Bridges, TM; Niswender, CM; Conn, PJ; Lindsley, CW Novel M Bioorg Med Chem Lett 29:362-366 (2019) [PubMed]  Article 
Target
Name:
Muscarinic acetylcholine receptor M4
Synonyms:
ACM4_HUMAN | CHRM4 | Cholinergic, muscarinic M4 | Muscarinic acetylcholine receptor | Muscarinic acetylcholine receptor M2 and M4
Type:
Enzyme Catalytic Domain
Mol. Mass.:
53079.31
Organism:
Homo sapiens (Human)
Description:
Cholinergic, muscarinic M4 CHRM4 HUMAN M3::P08173
Residue:
479
Sequence:
MANFTPVNGSSGNQSVRLVTSSSHNRYETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLACADLIIGAFSMNLYTVYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKQSVKKPPPGEAAREELRNGKLEEAPPPALPPPPRPVADKDTSNESSSGSATQNTKERPATELSTTEATTPAMPAPPLQPRALNPASRWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPDTVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTAR
  
Inhibitor
Name:
BDBM50518731
Synonyms:
CHEMBL4531650
Type:
Small organic molecule
Emp. Form.:
C16H20N4S
Mol. Mass.:
300.422
SMILES:
Cc1cc(C)c2c(n1)sc1c(NCC3CCCC3)n[nH]c21
Structure:
Search PDB for entries with ligand similarity: