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Target
Non-receptor tyrosine-protein kinase TYK2 [5-1181]
Ligand
BDBM50519520
Substrate
n/a
Meas. Tech.
ChEMBL_1875988 (CHEMBL4377382)
IC50
100±n/a nM
Citation
 Wrobleski, ST; Moslin, R; Lin, S; Zhang, Y; Spergel, S; Kempson, J; Tokarski, JS; Strnad, J; Zupa-Fernandez, A; Cheng, L; Shuster, D; Gillooly, K; Yang, X; Heimrich, E; McIntyre, KW; Chaudhry, C; Khan, J; Ruzanov, M; Tredup, J; Mulligan, D; Xie, D; Sun, H; Huang, C; D'Arienzo, C; Aranibar, N; Chiney, M; Chimalakonda, A; Pitts, WJ; Lombardo, L; Carter, PH; Burke, JR; Weinstein, DS Highly Selective Inhibition of Tyrosine Kinase 2 (TYK2) for the Treatment of Autoimmune Diseases: Discovery of the Allosteric Inhibitor BMS-986165. J Med Chem 62:8973-8995 (2019) [PubMed]  Article 
Target
Name:
Non-receptor tyrosine-protein kinase TYK2 [5-1181]
Synonyms:
Non-receptor tyrosine-protein kinase TYK2 | TYK2_MOUSE | Tyk2
Type:
PROTEIN
Mol. Mass.:
132654.63
Organism:
Mus musculus
Description:
ChEMBL_105608
Residue:
1177
Sequence:
MPLCGRRAILEDSKADGTEAQPLVPTGCLMVLLHWPGPEGGEPWVTFSQTSLTAEEVCIHIAHKVGITPPCLNLFALYNAQAKVWLPPNHILDTSQDMNLYFRMRFYFRNWHGMNPQEPAVYRCGFPGAETSSDRAEQGVQLLDSASFEYLFEQGKHEFMNDVVSLRDLSSEEEIHHFKNESLGMAFLHLCHLALSRGVPLEEMAREISFKNCIPHSFRQHIRQHNVLTRLRLHRVFRRFLRAFRPGHLSQQVVMVKYLATLERLAPRFGSERIPVCHLEVLAQPERDPCYIQNSGQTAGDPGPELPSGPPTHEVLVTGTGGIQWHPLQTQESERGNSRGNPHGSRSGKKPKAPKAGEHLTESPQEPPWTYFCDFQDISHVVLKERRVHIHLQDNKCLLLCLCSQAEALSFVALVDGYFRLTADSSHYLCHEVAPPRLVTSIQNGIHGPLMDPFVQAKLWPEDGLYLIQWSTSHLHRLILTVAHRNPAFSNGPRGLRLRKFPITQQPGAFVLDGWGRSFASLGDLRLALQGCSLRAGDDCFPLHHCCLPRPREISNLVIMRGSRAHTRPLNLSQLSFHRVHQDEITQLSHLGQGTRTNVYEGLLRVGGPDEGKVDNGCPPEPGGTSGQQLRVVLKVLDPSHHDIALAFYETASLMSQVSHMHLAFLHGVCVRGSENIIVTEFVEHGPLDVWLRRQRGQVPMTWKMVVAQQLASALSYLEDKNLVHGNVCGRNILLARLGLEEGTNPFIKLSDPGVGQGALSREERVERIPWTAPECLSGGTSSLGTATDMWGFGATLLEICFDGEAPLQGRGPSEKERFYTKKHQLPEPSSPELATLTRQCLTYEPAQRPSFRTILRDLTRLQPQNLVGTSAVNSDSPASDPTVFHKRYLKKIRDLGEGHFGKVSLYCYDPTNDGTGEMVAVKALKEGCGPQLRSGWQREIEILRTLYHEHIVKYKGCCEDQGEKSVQLVMEYVPLGSLRDYLPRHCVGLAQLLLFAQQICEGMAYLHAQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGHEYYRVREDGDSPVFWYAPECLKECKFYYASDVWSFGVTLYELLTYCDSNQSPHMKFTELIGHTQGQMTVLRLTELLERGERLPRPDRCPCEIYHLMKNCWETEASFRPTFQNLVPILQTAQEKYQGQVPSVF
  
Inhibitor
Name:
BDBM50519520
Synonyms:
CHEMBL4571117
Type:
Small organic molecule
Emp. Form.:
C21H23N7O3
Mol. Mass.:
424.4709
SMILES:
[2H]C([2H])([2H])NC(=O)c1cnc(NC(=O)C2CC2)cc1Nc1cccc(-c2ncn(C)n2)c1OC
Structure:
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