Reaction Details Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM50074092
Substrate
n/a
Meas. Tech.
ChEMBL_58610 (CHEMBL666180)
Ki
0.064±n/a nM
Citation
 Khalil, EM; Ojala, WH; Pradhan, A; Nair, VD; Gleason, WB; Mishra, RK; Johnson, RL Design, synthesis, and dopamine receptor modulating activity of spiro bicyclic peptidomimetics of L-prolyl-L-leucyl-glycinamide. J Med Chem 42:628-37 (1999) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50074092
Synonyms:
6'-oxo-1-[(2S)-tetrahydro-1H-2-pyrrolylcarbonyl]-(2'R,8a'R)-spiro[4H,5H-pyrrole-2,7'-perhydropyrrolo[2,1-b][1,3]thiazine]-4'-carboxamide | CHEMBL156164
Type:
Small organic molecule
Emp. Form.:
C16H24N4O3S
Mol. Mass.:
352.452
SMILES:
NC(=O)C1CCS[C@@H]2C[C@]3(CCCN3C(=O)[C@@H]3CCCN3)C(=O)N12
Structure:
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