Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50074398
Substrate
n/a
Meas. Tech.
ChEMBL_51132 (CHEMBL664193)
Ki
187±n/a nM
Citation
 Arvanitis, AGGilligan, PJChorvat, RJCheeseman, RSChristos, TEBakthavatchalam, RBeck, JPCocuzza, AJHobbs, FWWilde, RGArnold, CChidester, DCurry, MHe, LHollis, AKlaczkiewicz, JKrenitsky, PJRescinito, JPScholfield, ECulp, SDe Souza, EBFitzgerald, LGrigoriadis, DTam, SWShen, HL Non-peptide corticotropin-releasing hormone antagonists: syntheses and structure-activity relationships of 2-anilinopyrimidines and -triazines. J Med Chem 42:805-18 (1999) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF1 | CRFR1_RAT | CRH-R 1 | Corticotropin releasing factor receptor | Corticotropin releasing factor receptor 1 | Corticotropin-releasing Factor Receptor 1 | Corticotropin-releasing hormone receptor 1 | Crhr | Crhr1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
47870.75
Organism:
Rattus norvegicus (rat)
Description:
Receptor binding assays were performed using rat cortex homogenate.
Residue:
415
Sequence:
MGRRPQLRLVKALLLLGLNPVSTSLQDQRCENLSLTSNVSGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRSIRCLRNIIHWNLISAFILRNATWFVVQLTVSPEVHQSNVAWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFVCIGWGVPFPIIVAWAIGKLHYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWRRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50074398
Synonyms:
(2-Bromo-4-ethyl-phenyl)-(4,6-dimethyl-pyrimidin-2-yl)-methyl-amine | CHEMBL166102
Type:
Small organic molecule
Emp. Form.:
C15H18BrN3
Mol. Mass.:
320.228
SMILES:
CCc1ccc(N(C)c2nc(C)cc(C)n2)c(Br)c1
Structure:
Search PDB for entries with ligand similarity: