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Target
Proteasome assembly chaperone 1/2
Ligand
BDBM50520988
Substrate
n/a
Meas. Tech.
ChEMBL_1882722 (CHEMBL4384221)
IC50
>250000±n/a nM
Citation
 Ohsawa, K; Yoshida, M; Izumikawa, M; Takagi, M; Shin-Ya, K; Goshima, N; Hirokawa, T; Natsume, T; Doi, T Synthesis and biological evaluation of thielocin B1 analogues as protein-protein interaction inhibitors of PAC3 homodimer. Bioorg Med Chem 26:6023-6034 (2018) [PubMed]  Article 
Target
Name:
Proteasome assembly chaperone 1/2
Synonyms:
PAC1-PAC2 complex
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 1882722
Components:
This complex has 2 components.
Component 1
Name:
Proteasome assembly chaperone 1
Synonyms:
C21-LRP | Chromosome 21 leucine-rich protein | Down syndrome critical region protein 2 | PAC-1 | Proteasome assembly chaperone 1 | PSMG1_HUMAN | PSMG1 | C21LRP | DSCR2 | PAC1
Type:
PROTEIN
Mol. Mass.:
32855.57
Organism:
Human
Description:
ChEMBL_117168
Residue:
288
Sequence:
MAATFFGEVVKAPCRAGTEDEEEEEEGRRETPEDREVRLQLARKREVRLLRRQTKTSLEVSLLEKYPCSKFIIAIGNNAVAFLSSFVMNSGVWEEVGCAKLWNEWCRTTDTTHLSSTEAFCVFYHLKSNPSVFLCQCSCYVAEDQQYQWLEKVFGSCPRKNMQITILTCRHVTDYKTSESTGSLPSPFLRALKTQNFKDSACCPLLEQPNIVHDLPAAVLSYCQVWKIPAILYLCYTDVMKLDLITVEAFKPILSTRSLKGLVKNIPQSTEILKKLMTTNEIQSNIYT
  
Component 2
Name:
Proteasome assembly chaperone 2
Synonyms:
Hepatocellular carcinoma-susceptibility protein 3 | PAC-2 | Proteasome assembly chaperone 2 | Synonyms=HCCA3 | Tumor necrosis factor superfamily member 5-induced protein 1 | PSMG2_HUMAN | PSMG2 | HCCA3 | PAC2 | TNFSF5IP1
Type:
PROTEIN
Mol. Mass.:
29396.28
Organism:
Human
Description:
ChEMBL_117168
Residue:
264
Sequence:
MFVPCGESAPDLAGFTLLMPAVSVGNVGQLAMDLIISTLNMSKIGYFYTDCLVPMVGNNPYATTEGNSTELSINAEVYSLPSRKLVALQLRSIFIKYKSKPFCEKLLSWVKSSGCARVIVLSSSHSYQRNDLQLRSTPFRYLLTPSMQKSVQNKIKSLNWEEMEKSRCIPEIDDSEFCIRIPGGGITKTLYDESCSKEIQMAVLLKFVSEGDNIPDALGLVEYLNEWLQILKPLSDDPTVSASRWKIPSSWRLLFGSGLPPALF
  
Inhibitor
Name:
BDBM50520988
Synonyms:
CHEMBL4435319
Type:
Small organic molecule
Emp. Form.:
C53H58O17
Mol. Mass.:
967.03
SMILES:
COc1c(C)c(OC(=O)c2c(C)c(C)c(OC(=O)c3c(C)c(Oc4c(C)c(C)c(C(=O)Oc5c(C)c(C)c(C(O)=O)c(OC)c5C)c(OC)c4C)c(O)c(C)c3O)c(C)c2OC)c(C)c(C)c1C(O)=O
Structure:
Search PDB for entries with ligand similarity: