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Target
Prostaglandin E2 receptor EP3 subtype
Ligand
BDBM50142481
Substrate
n/a
Meas. Tech.
ChEMBL_1884833 (CHEMBL4386415)
Ki
1175±n/a nM
Citation
 Barrett, SD; Holt, MC; Kramer, JB; Germain, B; Ho, CS; Ciske, FL; Kornilov, A; Colombo, JM; Uzieblo, A; O'Malley, JP; Owen, TA; Stein, AJ; Morano, MI Difluoromethylene at the γ-Lactam α-Position Improves 11-Deoxy-8-aza-PGE J Med Chem 62:4731-4741 (2019) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP3 subtype
Synonyms:
Prostaglandin E2 receptor EP3A subtype (EP3A) | PGE2-R | Prostaglandin E2 receptor EP3 subtype | PGE receptor, EP3 subtype | Prostaglandin E2 receptor EP3 subtype (EP3) | Prostanoid EP3 receptor | Prostaglandin E2 receptor EP3D subtype (EP3D) | PE2R3_HUMAN | PTGER3 | Prostaglandin E2 receptor
Type:
Enzyme
Mol. Mass.:
43335.03
Organism:
Human
Description:
P43115
Residue:
390
Sequence:
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER
  
Inhibitor
Name:
BDBM50142481
Synonyms:
8-aza-11-deoxyprostaglandin E1 | 7-[(R)-2-((E)-(S)-3-Hydroxy-oct-1-enyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid | CHEMBL42027
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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