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Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM50142481
Substrate
n/a
Meas. Tech.
ChEMBL_1884837 (CHEMBL4386419)
EC50
0.065000±n/a nM
Citation
 Barrett, SD; Holt, MC; Kramer, JB; Germain, B; Ho, CS; Ciske, FL; Kornilov, A; Colombo, JM; Uzieblo, A; O'Malley, JP; Owen, TA; Stein, AJ; Morano, MI Difluoromethylene at the γ-Lactam α-Position Improves 11-Deoxy-8-aza-PGE J Med Chem 62:4731-4741 (2019) [PubMed]  Article 
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
Prostanoid EP4 receptor | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PE2R4_HUMAN | PTGER4 | PTGER2 | Prostaglandin E2 receptor
Type:
Enzyme
Mol. Mass.:
53134.53
Organism:
Human
Description:
P35408
Residue:
488
Sequence:
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
  
Inhibitor
Name:
BDBM50142481
Synonyms:
8-aza-11-deoxyprostaglandin E1 | 7-[(R)-2-((E)-(S)-3-Hydroxy-oct-1-enyl)-5-oxo-pyrrolidin-1-yl]-heptanoic acid | CHEMBL42027
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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