Reaction Details
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Cyclin-dependent kinase 4/G1/S-specific cyclin-D3
Ligand
BDBM50521925
Substrate
n/a
Meas. Tech.
ChEMBL_1885551 (CHEMBL4387133)
Ki
<0.300000±n/a nM
Citation
Bronner, SM; Merrick, KA; Murray, J; Salphati, L; Moffat, JG; Pang, J; Sneeringer, CJ; Dompe, N; Cyr, P; Purkey, H; Boenig, GL; Li, J; Kolesnikov, A; Larouche-Gauthier, R; Lai, KW; Shen, X; Aubert-Nicol, S; Chen, YC; Cheong, J; Crawford, JJ; Hafner, M; Haghshenas, P; Jakalian, A; Leclerc, JP; Lim, NK; O'Brien, T; Plise, EG; Shalan, H; Sturino, C; Wai, J; Xiao, Y; Yin, J; Zhao, L; Gould, S; Olivero, A; Heffron, TP Design of a brain-penetrant CDK4/6 inhibitor for glioblastoma. Bioorg Med Chem Lett 29:2294-2301 (2019) [PubMed] Article More Info.:
Target
Name:
Cyclin-dependent kinase 4/G1/S-specific cyclin-D3
Synonyms:
CDK4/Cyclin D3
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 1806445
Components:
This complex has 2 components.
Component 1
Name:
Cyclin-dependent kinase 4
Synonyms:
CDK4 | CDK4_HUMAN | Cell division protein kinase 4 | Cyclin-dependent kinase 4 (CDK 4) | PSK-J3
Type:
Enzyme Subunit
Mol. Mass.:
33731.96
Organism:
Homo sapiens (Human)
Description:
P11802
Residue:
303
Sequence:
MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE
Component 2
Name:
G1/S-specific cyclin-D3
Synonyms:
CCND3 | CCND3_HUMAN
Type:
Enzyme
Mol. Mass.:
32521.90
Organism:
Homo sapiens (Human)
Description:
P30281
Residue:
292
Sequence:
MELLCCEGTRHAPRAGPDPRLLGDQRVLQSLLRLEERYVPRASYFQCVQREIKPHMRKMLAYWMLEVCEEQRCEEEVFPLAMNYLDRYLSCVPTRKAQLQLLGAVCMLLASKLRETTPLTIEKLCIYTDHAVSPRQLRDWEVLVLGKLKWDLAAVIAHDFLAFILHRLSLPRDRQALVKKHAQTFLALCATDYTFAMYPPSMIATGSIGAAVQGLGACSMSGDELTELLAGITGTEVDCLRACQEQIEAALRESLREASQTSSSPAPKAPRGSSSQGPSQTSTPTDVTAIHL
Inhibitor
Name:
BDBM50521925
Synonyms:
CHEMBL4529532
Type:
Small organic molecule
Emp. Form.:
C26H32F2N8
Mol. Mass.:
494.5827
SMILES:
C[C@@H]1CCCCn2ncc(c12)-c1nc(Nc2ccc(cn2)N2CC3(CN(CCCF)C3)C2)ncc1F |r|
Structure:
