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Target
Endothelin-1 receptor
Ligand
BDBM50077930
Substrate
n/a
Meas. Tech.
ChEMBL_65479 (CHEMBL677308)
IC50
0.05±n/a nM
Citation
 Patt, WC; Cheng, XM; Repine, JT; Lee, C; Reisdorph, BR; Massa, MA; Doherty, AM; Welch, KM; Bryant, JW; Flynn, MA; Walker, DM; Schroeder, RL; Haleen, SJ; Keiser, JA Butenolide endothelin antagonists with improved aqueous solubility. J Med Chem 42:2162-8 (1999) [PubMed]  Article 
Target
Name:
Endothelin-1 receptor
Synonyms:
Endothelin receptor type A | ET-A | ETA-R | hET-AR | EDNRA_HUMAN | EDNRA | ETA | ETRA | Endothelin receptor, ET-A/ET-B
Type:
Enzyme Catalytic Domain
Mol. Mass.:
48736.88
Organism:
Human
Description:
P25101
Residue:
427
Sequence:
METLCLRASFWLALVGCVISDNPERYSTNLSNHVDDFTTFRGTELSFLVTTHQPTNLVLPSNGSMHNYCPQQTKITSAFKYINTVISCTIFIVGMVGNATLLRIIYQNKCMRNGPNALIASLALGDLIYVVIDLPINVFKLLAGRWPFDHNDFGVFLCKLFPFLQKSSVGITVLNLCALSVDRYRAVASWSRVQGIGIPLVTAIEIVSIWILSFILAIPEAIGFVMVPFEYRGEQHKTCMLNATSKFMEFYQDVKDWWLFGFYFCMPLVCTAIFYTLMTCEMLNRRNGSLRIALSEHLKQRREVAKTVFCLVVIFALCWFPLHLSRILKKTVYNEMDKNRCELLSFLLLMDYIGINLATMNSCINPIALYFVSKKFKNCFQSCLCCCCYQSKSLMTSVPMNGTSIQWKNHDQNNHNTDRSSHKDSMN
  
Inhibitor
Name:
BDBM50077930
Synonyms:
5-{5-[4-Benzo[1,3]dioxol-5-yl-2-hydroxy-2-(4-methoxy-phenyl)-5-oxo-2,5-dihydro-furan-3-ylmethyl]-2,3-dimethoxy-phenoxy}-pentanoic acid methyl ester | CHEMBL291058
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
COC(=O)CCCCOc1cc(CC2=C(C(=O)OC2(O)c2ccc(OC)cc2)c2ccc3OCOc3c2)cc(OC)c1OC |t:13|
Structure:
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