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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50523022
Substrate
n/a
Meas. Tech.
ChEMBL_1888841 (CHEMBL4390518)
EC50
720±n/a nM
Citation
 Harada, K; Mizukami, J; Watanabe, T; Mori, G; Ubukata, M; Suwa, K; Fukuda, S; Negoro, T; Sato, M; Inaba, T Optimization of oxadiazole derivatives with a spirocyclic cyclohexane structure as novel GPR119 agonists. Bioorg Med Chem Lett 29:2100-2106 (2019) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50523022
Synonyms:
CHEMBL4549349
Type:
Small organic molecule
Emp. Form.:
C21H27FN2O5S
Mol. Mass.:
438.513
SMILES:
CC(O[C@H]1CC[C@]2(CCCO2)CC1)c1nc(no1)-c1ccc(CS(C)(=O)=O)c(F)c1 |r,wU:6.10,3.2,(75.67,-5.53,;75.68,-7.07,;77.09,-7.69,;78.34,-6.79,;78.18,-5.26,;79.44,-4.35,;80.86,-4.99,;82.35,-5.38,;83.17,-4.09,;82.21,-2.89,;80.77,-3.45,;81,-6.53,;79.76,-7.42,;74.44,-7.97,;72.97,-7.5,;72.06,-8.75,;72.97,-10,;74.44,-9.52,;70.52,-8.75,;69.75,-7.41,;68.21,-7.42,;67.44,-8.75,;65.91,-8.76,;65.13,-7.42,;63.6,-7.43,;65.52,-5.93,;66.62,-7.02,;68.21,-10.08,;67.44,-11.41,;69.75,-10.08,)|
Structure:
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