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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50523023
Substrate
n/a
Meas. Tech.
ChEMBL_1888841 (CHEMBL4390518)
EC50
86±n/a nM
Citation
 Harada, K; Mizukami, J; Watanabe, T; Mori, G; Ubukata, M; Suwa, K; Fukuda, S; Negoro, T; Sato, M; Inaba, T Optimization of oxadiazole derivatives with a spirocyclic cyclohexane structure as novel GPR119 agonists. Bioorg Med Chem Lett 29:2100-2106 (2019) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50523023
Synonyms:
CHEMBL4454946
Type:
Small organic molecule
Emp. Form.:
C22H29FN2O5S
Mol. Mass.:
452.539
SMILES:
CC(O[C@H]1CC[C@]2(CCCCO2)CC1)c1nc(no1)-c1ccc(CS(C)(=O)=O)c(F)c1 |r,wU:6.11,3.2,(18.4,-20.13,;18.41,-21.67,;19.83,-22.3,;21.08,-21.39,;20.91,-19.86,;22.17,-18.95,;23.59,-19.59,;24.92,-20.35,;26.24,-19.59,;26.24,-18.06,;24.92,-17.29,;23.59,-18.06,;23.74,-21.13,;22.49,-22.02,;17.17,-22.57,;15.7,-22.1,;14.79,-23.35,;15.7,-24.6,;17.17,-24.12,;13.25,-23.35,;12.48,-22.01,;10.94,-22.02,;10.17,-23.35,;8.63,-23.36,;7.85,-22.02,;6.32,-22.03,;8.25,-20.53,;9.34,-21.62,;10.94,-24.68,;10.17,-26.02,;12.48,-24.68,)|
Structure:
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