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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50523025
Substrate
n/a
Meas. Tech.
ChEMBL_1888841 (CHEMBL4390518)
EC50
27±n/a nM
Citation
 Harada, K; Mizukami, J; Watanabe, T; Mori, G; Ubukata, M; Suwa, K; Fukuda, S; Negoro, T; Sato, M; Inaba, T Optimization of oxadiazole derivatives with a spirocyclic cyclohexane structure as novel GPR119 agonists. Bioorg Med Chem Lett 29:2100-2106 (2019) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50523025
Synonyms:
CHEMBL4525262
Type:
Small organic molecule
Emp. Form.:
C22H26F4N2O5S
Mol. Mass.:
506.511
SMILES:
C[C@@H](O[C@H]1CC[C@@]2(CC1)CC(F)(F)CCO2)c1nc(no1)-c1cc(F)c(CS(C)(=O)=O)c(F)c1 |r,wU:6.16,3.2,1.0,(70.22,-20.36,;70.23,-21.9,;71.64,-22.53,;72.89,-21.63,;72.73,-20.09,;73.99,-19.18,;75.41,-19.82,;75.56,-21.36,;74.31,-22.26,;76.74,-20.59,;78.06,-19.82,;79.59,-19.82,;78.82,-21.15,;78.06,-18.29,;76.74,-17.52,;75.4,-18.29,;68.99,-22.81,;67.52,-22.33,;66.61,-23.58,;67.52,-24.83,;68.99,-24.35,;65.06,-23.58,;64.3,-24.92,;62.76,-24.91,;61.98,-26.25,;61.98,-23.59,;60.45,-23.59,;59.67,-22.26,;58.14,-22.27,;60.06,-20.77,;61.15,-21.85,;62.75,-22.25,;61.98,-20.92,;64.3,-22.25,)|
Structure:
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