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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50523026
Substrate
n/a
Meas. Tech.
ChEMBL_1888841 (CHEMBL4390518)
EC50
2457±n/a nM
Citation
 Harada, K; Mizukami, J; Watanabe, T; Mori, G; Ubukata, M; Suwa, K; Fukuda, S; Negoro, T; Sato, M; Inaba, T Optimization of oxadiazole derivatives with a spirocyclic cyclohexane structure as novel GPR119 agonists. Bioorg Med Chem Lett 29:2100-2106 (2019) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50523026
Synonyms:
CHEMBL4442686
Type:
Small organic molecule
Emp. Form.:
C24H32FN3O4
Mol. Mass.:
445.527
SMILES:
CC(O[C@H]1CC[C@@]2(COC(C)(C)C2)CC1)c1nc(no1)-c1ccc(C(=O)N(C)C)c(F)c1 |r,wU:6.6,3.2,(74.53,-5.31,;74.54,-6.86,;75.95,-7.48,;77.2,-6.58,;77.04,-5.05,;78.3,-4.14,;79.71,-4.78,;79.63,-3.24,;81.07,-2.68,;82.03,-3.88,;83.36,-3.09,;83.37,-4.64,;81.2,-5.17,;79.86,-6.31,;78.61,-7.21,;73.3,-7.76,;71.83,-7.28,;70.92,-8.53,;71.83,-9.78,;73.3,-9.3,;69.38,-8.53,;68.62,-7.2,;67.07,-7.2,;66.31,-8.54,;64.77,-8.54,;64.01,-9.87,;64,-7.21,;64.76,-5.88,;62.46,-7.22,;67.08,-9.86,;66.3,-11.2,;68.62,-9.86,)|
Structure:
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