Reaction Details Report a problem with these data
Target
Vasopressin V1a receptor
Ligand
BDBM50078645
Substrate
n/a
Meas. Tech.
ChEBML_211231
IC50
59±n/a nM
Citation
 Aranapakam, V; Albright, JD; Grosu, GT; Chan, PS; Coupet, J; Saunders, T; Ru, X; Mazandarani, H 4,10-dihydro-5H-thieno[3,2-c][1]benzazepine derivatives and 9,10-dihydro-4H-thieno[2,3-c][1]benzazepine derivatives as orally active arginine vasopressin receptor antagonists. Bioorg Med Chem Lett 9:1733-6 (1999) [PubMed]  Article 
Target
Name:
Vasopressin V1a receptor
Synonyms:
Avpr1a | V1AR_RAT | VASOPRESSIN V1A | Vasopressin V1 receptor | Vasopressin V1a receptor | Vasopressin receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
47674.81
Organism:
Rat
Description:
VASOPRESSIN V1A AVPR1A RAT::P30560
Residue:
424
Sequence:
MSFPRGSQDRSVGNSSPWWPLTTEGSNGSQEAARLGEGDSPLGDVRNEELAKLEIAVLAVIFVVAVLGNSSVLLALHRTPRKTSRMHLFIRHLSLADLAVAFFQVLPQLCWDITYRFRGPDWLCRVVKHLQVFAMFASAYMLVVMTADRYIAVCHPLKTLQQPARRSRLMIATSWVLSFILSTPQYFIFSVIEIEVNNGTKTQDCWATFIQPWGTRAYVTWMTSGVFVAPVVVLGTCYGFICYHIWRNIRGKTASSRHSKGDKGSGEAVGPFHKGLLVTPCVSSVKSISRAKIRTVKMTFVIVSAYILCWAPFFIVQMWSVWDENFIWTDSENPSITITALLASLNSCCNPWIYMFFSGHLLQDCVQSFPCCHSMAQKFAKDDSDSMSRRQTSYSNNRSPTNSTGMWKDSPKSSKSIRFIPVST
  
Inhibitor
Name:
BDBM50078645
Synonyms:
CHEMBL296814 | N-[5-(4,10-Dihydro-1-thia-9-aza-benzo[f]azulene-9-carbonyl)-pyridin-2-yl]-5-fluoro-2-methyl-benzamide
Type:
Small organic molecule
Emp. Form.:
C26H20FN3O2S
Mol. Mass.:
457.519
SMILES:
Cc1ccc(F)cc1C(=O)Nc1ccc(cn1)C(=O)N1Cc2sccc2Cc2ccccc12
Structure:
Search PDB for entries with ligand similarity: