Reaction Details Report a problem with these data
Target
Thiosulfate sulfurtransferase
Ligand
BDBM71542
Substrate
n/a
Meas. Tech.
ChEMBL_1891102 (CHEMBL4392929)
IC50
2900±n/a nM
Citation
 Stevens, M; Abdeen, S; Salim, N; Ray, AM; Washburn, A; Chitre, S; Sivinski, J; Park, Y; Hoang, QQ; Chapman, E; Johnson, SM HSP60/10 chaperonin systems are inhibited by a variety of approved drugs, natural products, and known bioactive molecules. Bioorg Med Chem Lett 29:1106-1112 (2019) [PubMed]  Article 
Target
Name:
Thiosulfate sulfurtransferase
Synonyms:
2.8.1.1 | Rhodanese | THTR_HUMAN | TST | Thiosulfate sulfurtransferase
Type:
PROTEIN
Mol. Mass.:
33432.06
Organism:
Homo sapiens
Description:
ChEMBL_118080
Residue:
297
Sequence:
MVHQVLYRALVSTKWLAESIRTGKLGPGLRVLDASWYSPGTREARKEYLERHVPGASFFDIEECRDTASPYEMMLPSEAGFAEYVGRLGISNHTHVVVYDGEHLGSFYAPRVWWMFRVFGHRTVSVLNGGFRNWLKEGHPVTSEPSRPEPAVFKATLDRSLLKTYEQVLENLESKRFQLVDSRSQGRFLGTEPEPDAVGLDSGHIRGAVNMPFMDFLTEDGFEKGPEELRALFQTKKVDLSQPLIATCRKGVTACHVALAAYLCGKPDVAVYDGSWSEWFRRAPPESRVSQGKSEKA
  
Inhibitor
Name:
BDBM71542
Synonyms:
(4-amino-1-methyl-butyl)-(6-methoxy-8-quinolyl)amine;phosphoric acid | 4-N-(6-methoxyquinolin-8-yl)pentane-1,4-diamine;phosphoric acid | MLS001334045 | N4-(6-methoxy-8-quinolinyl)pentane-1,4-diamine;phosphoric acid | N4-(6-methoxyquinolin-8-yl)pentane-1,4-diamine;phosphoric acid | Primaquine bisphosphate | SMR000875314 | cid_359247
Type:
Small organic molecule
Emp. Form.:
C15H21N3O
Mol. Mass.:
259.3467
SMILES:
COc1cc(NC(C)CCCN)c2ncccc2c1
Structure:
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