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Target
Vasopressin V2 receptor
Ligand
BDBM50205308
Substrate
n/a
Meas. Tech.
ChEMBL_1895477 (CHEMBL4397512)
EC50
0.030000±n/a nM
Citation
 Wiśniewski, K; Qi, S; Kraus, J; Ly, B; Srinivasan, K; Tariga, H; Croston, G; La, E; Wiśniewska, H; Ortiz, C; Laporte, R; Rivière, PJ; Neyer, G; Hargrove, DM; Schteingart, CD Discovery of Potent, Selective, and Short-Acting Peptidic V J Med Chem 62:4991-5005 (2019) [PubMed]  Article 
Target
Name:
Vasopressin V2 receptor
Synonyms:
VASOPRESSIN V2 | Renal-type arginine vasopressin receptor | AVPR V2 | Antidiuretic hormone receptor | V2R_RAT | Avpr2 | Vasopressin receptor
Type:
G-protein coupled receptor
Mol. Mass.:
40761.85
Organism:
Rat
Description:
n/a
Residue:
371
Sequence:
MLLVSTVSAVPGLFSPPSSPSNSSQEELLDDRDPLLVRAELALLSTIFVAVALSNGLVLGALIRRGRRGRWAPMHVFISHLCLADLAVALFQVLPQLAWDATDRFHGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGGGARWNRPVLVAWAFSLLLSLPQLFIFAQRDVGNGSGVFDCWARFAEPWGLRAYVTWIALMVFVAPALGIAACQVLIFREIHASLVPGPSERAGRRRRGRRTGSPSEGAHVSAAMAKTVRMTLVIVIVYVLCWAPFFLVQLWAAWDPEAPLERPPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCAQRHTTHSLGPQDESCATASSSLMKDTPS
  
Inhibitor
Name:
BDBM50205308
Synonyms:
CHEMBL1429 | (S)-1-((4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl)-N-((R)-1-(2-amino-2-oxoethylamino)-5-guanidino-1-oxopentan-2-yl)pyrrolidine-2-carboxamide | dDAVP | DESMOPRESSIN | US10131692, Compound 42 (dDAVP)
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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