Reaction Details Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM21398
Substrate
n/a
Meas. Tech.
ChEMBL_58759 (CHEMBL669147)
Ki
0.16±n/a nM
Citation
 Höök, BB; Brege, C; Linnanen, T; Mikaels, A; Malmberg, A; Johansson, AM Derivatives of (R)-2-amino-5-methoxytetralin: antagonists and inverse agonists at the dopamine D2A receptor. Bioorg Med Chem Lett 9:2167-72 (1999) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2 | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Human
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM21398
Synonyms:
4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1-(4-fluoro-phenyl)-butan-1-one;propionate(HCl) | Haloperidol, 1 | CHEMBL545608 | CHEMBL54 | 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one | Haloperidol | US20240317745, Compound haloperidol
Type:
Small organic molecule
Emp. Form.:
C21H23ClFNO2
Mol. Mass.:
375.14
SMILES:
c1cc(ccc1C(=O)CCCN2CCC(CC2)(c3ccc(cc3)Cl)O)F
Structure:
Search PDB for entries with ligand similarity: