Target
Calpain-1 catalytic subunit
Ligand
BDBM50080211
Substrate
n/a
Meas. Tech.
ChEMBL_43861 (CHEMBL658521)
Ki
71±n/a nM
Citation
 Chatterjee, SDunn, DTao, MWells, GGu, ZQBihovsky, RAtor, MASiman, RMallamo, JP P2-achiral, P'-extended alpha-ketoamide inhibitors of calpain I. Bioorg Med Chem Lett 9:2371-4 (1999) [PubMed]  Article 
Target
Name:
Calpain-1 catalytic subunit
Synonyms:
CAN1_HUMAN | CANPL1 | CAPN1 | Calpain ยต-type | Calpain-1 (u-Calpain) | Calpain-1 catalytic subunit | Calpain1
Type:
Protein
Mol. Mass.:
81880.51
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
714
Sequence:
MSEEIITPVYCTGVSAQVQKQRARELGLGRHENAIKYLGQDYEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLWQFGEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGFEDFTGGVTEWYELRKAPSDLYQIILKALERGSLLGCSIDISSVLDMEAITFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERDQLRVKMEDGEFWMSFRDFMREFTRLEICNLTPDALKSRTIRKWNTTLYEGTWRRGSTAGGCRNYPATFWVNPQFKIRLDETDDPDDYGDRESGCSFVLALMQKHRRRERRFGRDMETIGFAVYEVPPELVGQPAVHLKRDFFLANASRARSEQFINLREVSTRFRLPPGEYVVVPSTFEPNKEGDFVLRFFSEKSAGTVELDDQIQANLPDEQVLSEEEIDENFKALFRQLAGEDMEISVKELRTILNRIISKHKDLRTKGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLSIFRKFDLDKSGSMSAYEMRMAIESAGFKLNKKLYELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKTLDTDLDGVVTFDLFKWLQLTMFA
  
Inhibitor
Name:
BDBM50080211
Synonyms:
CHEMBL309639 | N-((S)-2-{2-[4-(4-Acetyl-piperazin-1-ylmethyl)-benzenesulfonylamino]-ethylcarbamoyl}-1-benzyl-2-oxo-ethyl)-2,6-dichloro-benzamide
Type:
Small organic molecule
Emp. Form.:
C32H35Cl2N5O6S
Mol. Mass.:
688.621
SMILES:
CC(=O)N1CCN(Cc2ccc(cc2)S(=O)(=O)NCCNC(=O)C(=O)[C@H](Cc2ccccc2)NC(=O)c2c(Cl)cccc2Cl)CC1
Structure:
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