Reaction Details Report a problem with these data
Target
Cytosolic phospholipase A2
Ligand
BDBM50526358
Substrate
n/a
Meas. Tech.
ChEMBL_1899863 (CHEMBL4401978)
IC50
22000±n/a nM
Citation
 Dedaki, C; Kokotou, MG; Mouchlis, VD; Limnios, D; Lei, X; Mu, CT; Ramanadham, S; Magrioti, V; Dennis, EA; Kokotos, G β-Lactones: A Novel Class of Ca J Med Chem 62:2916-2927 (2019) [PubMed]  Article 
Target
Name:
Cytosolic phospholipase A2
Synonyms:
Lysophospholipase | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 | Phospholipase A2 group IVA | PA24A_HUMAN | PLA2G4A | CPLA2 | PLA2G4
Type:
Protein
Mol. Mass.:
85219.30
Organism:
Human
Description:
P47712
Residue:
749
Sequence:
MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRTRHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFTVSSMKVGEKKEVPFIFNQVTEMVLEMSLEVCSCPDLRFSMALCDQEKTFRQQRKEHIRESMKKLLGPKNSEGLHSARDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWYMSTLYSHPDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIGETLIHNRMNTTLSSLKEKVNTAQCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYGTFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQSRGSTMEEELENITTKHIVSNDSSDSDDESHEPKGTENEDAGSDYQSDNQASWIHRMIMALVSDSALFNTREGRAGKVHNFMLGLNLNTSYPLSPLSDFATQDSFDDDELDAAVADPDEFERIYEPLDVKSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMNKLPFPKIDPYVFDREGLKECYVFKPKNPDMEKDCPTIIHFVLANINFRKYRAPGVPRETEEEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMHFNTLNNIDVIKEAMVESIEYRRQNPSRCSVSLSNVEARRFFNKEFLSKPKA
  
Inhibitor
Name:
BDBM50526358
Synonyms:
CHEMBL4476476
Type:
Small organic molecule
Emp. Form.:
C16H22O2
Mol. Mass.:
246.35
SMILES:
CCC[C@H]1OC(=O)[C@@H]1CCCCc1ccccc1 |r|
Structure:
Search PDB for entries with ligand similarity: