Reaction Details Report a problem with these data
Target
Adenosine receptor A3
Ligand
BDBM21220
Substrate
n/a
Meas. Tech.
ChEMBL_1903811 (CHEMBL4406033)
EC50
188±n/a nM
Citation
 Tosh, DK; Salmaso, V; Rao, H; Bitant, A; Fisher, CL; Lieberman, DI; Vorbrüggen, H; Reitman, ML; Gavrilova, O; Gao, ZG; Auchampach, JA; Jacobson, KA Truncated (N)-Methanocarba Nucleosides as Partial Agonists at Mouse and Human A J Med Chem 63:4334-4348 (2020) [PubMed]  Article 
Target
Name:
Adenosine receptor A3
Synonyms:
A3AR | Adenosine A3 receptor | AA3R_MOUSE | Adora3 | Gpcr2
Type:
PROTEIN
Mol. Mass.:
36460.91
Organism:
Mouse
Description:
ChEMBL_1515686
Residue:
319
Sequence:
MEADNTTETDWLNITYITMEAAIGLCAVVGNMLVIWVVKLNPTLRTTTVYFIVSLALADIAVGVLVIPLAIAVSLQVKMHFYACLFMSCVLLIFTHASIMSLLAIAVHRYLRVKLTVRYRTVTTQRRIWLFLGLCWLVSFLVGLTPMFGWNRKATLASSQNSSTLLCHFRSVVSLDYMVFFSFITWILVPLVVMCIIYLDIFYIIRNKLSQNLTGFRETRAFYGREFKTAKSLFLVLFLFALCWLPLSIINFVSYFDVKIPDVAMCLGILLSHANSMMNPIVYACKIKKFKETYFLILRAVRLCQTSDSLDSNMEQTTE
  
Inhibitor
Name:
BDBM21220
Synonyms:
CHEMBL464859 | N-Ethylcarboxamidoadenosine | Adenosine-5-(N-ethylcarboxamide) | (2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-N-ethyl-3,4-dihydroxyoxolane-2-carboxamide | Adenosine, N6-Ethyl-carboxamido | Adenosine analog, 3 | NECA
Type:
Antineoplastic Agent
Emp. Form.:
C12H16N6O4
Mol. Mass.:
308.12
SMILES:
CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(N)ncnc12
Structure:
Search PDB for entries with ligand similarity: