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Target
Histamine H1 receptor
Ligand
BDBM50073179
Substrate
n/a
Meas. Tech.
ChEMBL_1908194 (CHEMBL4410552)
IC50
1.8±n/a nM
Citation
 Li, F; Xu, Q; Zhu, Q; Chu, Z; Lin, G; Mo, J; Zhao, Y; Li, J; He, G; Xu, Y Design, synthesis and biological evaluation of novel desloratadine derivatives with anti-inflammatory and H Bioorg Med Chem Lett 29:0 (2019) [PubMed]  Article 
Target
Name:
Histamine H1 receptor
Synonyms:
HISTAMINE H1 | H1R | HH1R | HRH1_HUMAN | HRH1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
55808.72
Organism:
Human
Description:
Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay.
Residue:
487
Sequence:
MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLRPENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKLYCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSRTDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFIMAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFKRILHIRS
  
Inhibitor
Name:
BDBM50073179
Synonyms:
CHEMBL1172 | Clarinex | Claritin-D | Claritin | SCH-34117 | 8-Chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine | DESLORATADINE | US9333199, DESLORATADINE (Clarinex) | US9138431, DESLORATADINE (Clarinex)
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: