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Target
Neutrophil elastase
Ligand
BDBM50084228
Substrate
n/a
Meas. Tech.
ChEMBL_86536 (CHEMBL699955)
Kd
5500±n/a nM
Citation
 Gütschow, M; Kuerschner, L; Neumann, U; Pietsch, M; Löser, R; Koglin, N; Eger, K 2-(diethylamino)thieno1,3??xazin-4-ones as stable inhibitors of human leukocyte elastase. J Med Chem 42:5437-47 (2000) [PubMed]  Article 
Target
Name:
Neutrophil elastase
Synonyms:
Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin
Type:
Enzyme
Mol. Mass.:
28532.38
Organism:
Homo sapiens (Human)
Description:
P08246
Residue:
267
Sequence:
MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLIAPNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVILQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSLCRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVNWIDSIIQRSEDNPCPHPRDPDPASRTH
  
Inhibitor
Name:
BDBM50084228
Synonyms:
2-(diethylamino)-5-methyl-4H-thieno[2,3-d][1,3]oxazin-4-one | 2-Diethylamino-5-methyl-thieno[2,3-d][1,3]oxazin-4-one | CHEMBL153631
Type:
Small organic molecule
Emp. Form.:
C11H14N2O2S
Mol. Mass.:
238.306
SMILES:
CCN(CC)c1nc2scc(C)c2c(=O)o1
Structure:
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