Reaction Details Report a problem with these data
Target
Short transient receptor potential channel 5
Ligand
BDBM50529447
Substrate
n/a
Meas. Tech.
ChEMBL_1908620 (CHEMBL4410978)
IC50
530±n/a nM
Citation
 Yu, M; Ledeboer, MW; Daniels, M; Malojcic, G; Tibbitts, TT; Coeffet-Le Gal, M; Pan-Zhou, XR; Westerling-Bui, A; Beconi, M; Reilly, JF; Mundel, P; Harmange, JC Discovery of a Potent and Selective TRPC5 Inhibitor, Efficacious in a Focal Segmental Glomerulosclerosis Model. ACS Med Chem Lett 10:1579-1585 (2019) [PubMed]  Article 
Target
Name:
Short transient receptor potential channel 5
Synonyms:
TRP5 | TRPC5 | TRPC5_HUMAN | Transient receptor protein 5 (TRPC5)
Type:
Enzyme
Mol. Mass.:
111421.47
Organism:
Homo sapiens (Human)
Description:
Q9UL62
Residue:
973
Sequence:
MAQLYYKKVNYSPYRDRIPLQIVRAETELSAEEKAFLNAVEKGDYATVKQALQEAEIYYNVNINCMDPLGRSALLIAIENENLEIMELLLNHSVYVGDALLYAIRKEVVGAVELLLSYRRPSGEKQVPTLMMDTQFSEFTPDITPIMLAAHTNNYEIIKLLVQKRVTIPRPHQIRCNCVECVSSSEVDSLRHSRSRLNIYKALASPSLIALSSEDPILTAFRLGWELKELSKVENEFKAEYEELSQQCKLFAKDLLDQARSSRELEIILNHRDDHSEELDPQKYHDLAKLKVAIKYHQKEFVAQPNCQQLLATLWYDGFPGWRRKHWVVKLLTCMTIGFLFPMLSIAYLISPRSNLGLFIKKPFIKFICHTASYLTFLFMLLLASQHIVRTDLHVQGPPPTVVEWMILPWVLGFIWGEIKEMWDGGFTEYIHDWWNLMDFAMNSLYLATISLKIVAYVKYNGSRPREEWEMWHPTLIAEALFAISNILSSLRLISLFTANSHLGPLQISLGRMLLDILKFLFIYCLVLLAFANGLNQLYFYYETRAIDEPNNCKGIRCEKQNNAFSTLFETLQSLFWSVFGLLNLYVTNVKARHEFTEFVGATMFGTYNVISLVVLLNMLIAMMNNSYQLIADHADIEWKFARTKLWMSYFDEGGTLPPPFNIIPSPKSFLYLGNWFNNTFCPKRDPDGRRRRRNLRSFTERNADSLIQNQHYQEVIRNLVKRYVAAMIRNSKTHEGLTEENFKELKQDISSFRYEVLDLLGNRKHPRSFSTSSTELSQRDDNNDGSGGARAKSKSVSFNLGCKKKTCHGPPLIRTMPRSSGAQGKSKAESSSKRSFMGPSLKKLGLLFSKFNGHMSEPSSEPMYTISDGIVQQHCMWQDIRYSQMEKGKAEACSQSEINLSEVELGEVQGAAQSSECPLACSSSLHCASSICSSNSKLLDSSEDVFETWGEACDLLMHKWGDGQEEQVTTRL
  
Inhibitor
Name:
BDBM50529447
Synonyms:
CHEMBL4517031
Type:
Small organic molecule
Emp. Form.:
C16H23ClN4O2
Mol. Mass.:
338.832
SMILES:
C[C@H]1CC[C@H](CN2CCN(CC2=O)c2cn[nH]c(=O)c2Cl)CC1 |r,wU:4.4,wD:1.0,(47.27,-39.08,;48.6,-38.32,;49.94,-39.1,;51.28,-38.34,;51.28,-36.8,;52.62,-36.04,;53.95,-36.83,;53.93,-38.37,;55.27,-39.16,;56.6,-38.39,;56.61,-36.85,;55.29,-36.07,;55.3,-34.53,;57.93,-39.17,;59.26,-38.4,;60.6,-39.16,;60.6,-40.71,;59.27,-41.48,;59.26,-43.02,;57.93,-40.71,;56.6,-41.48,;49.96,-36.02,;48.62,-36.78,)|
Structure:
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