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Target
Kappa-type opioid receptor
Ligand
BDBM50529522
Substrate
n/a
Meas. Tech.
ChEMBL_1908762 (CHEMBL4411120)
Ki
0.100000±n/a nM
Citation
 Long, DD; Armstrong, SR; Beattie, DT; Campbell, CB; Church, TJ; Colson, PJ; Dalziel, SM; Jacobsen, JR; Jiang, L; Obedencio, GP; Rapta, M; Saito, D; Stergiades, I; Tsuruda, PR; Van Dyke, PM; Vickery, RG Discovery of Axelopran (TD-1211): A Peripherally Restricted ?-Opioid Receptor Antagonist. ACS Med Chem Lett 10:1641-1647 (2019) [PubMed]  Article 
Target
Name:
Kappa-type opioid receptor
Synonyms:
Kappa Opioid Receptor | OPIATE Kappa | OPRK1 | OPRK_CAVPO | Opiate Kappa 1 | mu/kappa opioid receptor
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42744.99
Organism:
Cavia porcellus (domestic guinea pig)
Description:
P41144
Residue:
380
Sequence:
MGRRRQGPAQPASELPARNACLLPNGSAWLPGWAEPDGNGSAGPQDEQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIILGGTKVREDVDIIECSLQFPDDDYSWWDLFMKICVFVFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFIICWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPIKMRMERQSTSRVRNTVQDPAYMRNVDGVNKPV
  
Inhibitor
Name:
BDBM50529522
Synonyms:
CHEMBL4471516
Type:
Small organic molecule
Emp. Form.:
C28H37N3O3
Mol. Mass.:
463.6117
SMILES:
[H][C@]12CC[C@]([H])(C[C@@H](C1)c1cccc(c1)C(N)=O)N2CCN(CC1CCCCC1)C(=O)c1ccco1 |r,TLB:9:7:18:3.2|
Structure:
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