Reaction Details Report a problem with these data
Target
Discoidin domain-containing receptor 2
Ligand
BDBM50529763
Substrate
n/a
Meas. Tech.
ChEMBL_1909870 (CHEMBL4412316)
IC50
3.9±n/a nM
Citation
 Wang, Q; Dai, Y; Ji, Y; Shi, H; Guo, Z; Chen, D; Chen, Y; Peng, X; Gao, Y; Wang, X; Chen, L; Jiang, Y; Geng, M; Shen, J; Ai, J; Xiong, B Discovery and optimization of a series of 3-substituted indazole derivatives as multi-target kinase inhibitors for the treatment of lung squamous cell carcinoma. Eur J Med Chem 163:671-689 (2019) [PubMed]  Article 
Target
Name:
Discoidin domain-containing receptor 2
Synonyms:
DDR2 | DDR2_HUMAN | Discoidin domain receptor 2 (DDR2) | Discoidin domain-containing receptor 2 | Discoidin domain-containing receptor 2 (DDR2) | Epithelial discoidin domain-containing receptor 2 (DDR2) | NTRKR3 | TKT | TYRO10
Type:
Protein
Mol. Mass.:
96717.07
Organism:
Homo sapiens (Human)
Description:
Q16832
Residue:
855
Sequence:
MILIPRMLLVLFLLLPILSSAKAQVNPAICRYPLGMSGGQIPDEDITASSQWSESTAAKYGRLDSEEGDGAWCPEIPVEPDDLKEFLQIDLHTLHFITLVGTQGRHAGGHGIEFAPMYKINYSRDGTRWISWRNRHGKQVLDGNSNPYDIFLKDLEPPIVARFVRFIPVTDHSMNVCMRVELYGCVWLDGLVSYNAPAGQQFVLPGGSIIYLNDSVYDGAVGYSMTEGLGQLTDGVSGLDDFTQTHEYHVWPGYDYVGWRNESATNGYIEIMFEFDRIRNFTTMKVHCNNMFAKGVKIFKEVQCYFRSEASEWEPNAISFPLVLDDVNPSARFVTVPLHHRMASAIKCQYHFADTWMMFSEITFQSDAAMYNNSEALPTSPMAPTTYDPMLKVDDSNTRILIGCLVAIIFILLAIIVIILWRQFWQKMLEKASRRMLDDEMTVSLSLPSDSSMFNNNRSSSPSEQGSNSTYDRIFPLRPDYQEPSRLIRKLPEFAPGEEESGCSGVVKPVQPSGPEGVPHYAEADIVNLQGVTGGNTYSVPAVTMDLLSGKDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHEPPNSSSSDVRTVSYTNLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFCQEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQEIHLLLLQQGDE
  
Inhibitor
Name:
BDBM50529763
Synonyms:
CHEMBL4521671
Type:
Small organic molecule
Emp. Form.:
C29H30F3N5O
Mol. Mass.:
521.5766
SMILES:
CCN1CCN(Cc2cc(NC(=O)c3ccc(C)c(c3)-c3ccc4cn[nH]c4c3)cc(c2)C(F)(F)F)CC1
Structure:
Search PDB for entries with ligand similarity: