Reaction Details Report a problem with these data
Target
Cytochrome P450 3A4
Ligand
BDBM250082
Substrate
n/a
Meas. Tech.
ChEMBL_1912369 (CHEMBL4414952)
IC50
60600±n/a nM
Citation
Guo, Y; Liu, Y; Hu, N; Yu, D; Zhou, C; Shi, G; Zhang, B; Wei, M; Liu, J; Luo, L; Tang, Z; Song, H; Guo, Y; Liu, X; Su, D; Zhang, S; Song, X; Zhou, X; Hong, Y; Chen, S; Cheng, Z; Young, S; Wei, Q; Wang, H; Wang, Q; Lv, L; Wang, F; Xu, H; Sun, H; Xing, H; Li, N; Zhang, W; Wang, Z; Liu, G; Sun, Z; Zhou, D; Li, W; Liu, L; Wang, L; Wang, Z Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase. J Med Chem 62:7923-7940 (2019) [PubMed] Article
More Info.:
Target
Name:
Cytochrome P450 3A4
Synonyms:
Albendazole monooxygenase | Albendazole sulfoxidase | CP3A4_HUMAN | CYP3A3 | CYP3A4 | CYPIIIA3 | CYPIIIA4 | Cytochrome P450 3A3 | Cytochrome P450 3A4 (CYP3A4) | Cytochrome P450 HLp | Nifedipine oxidase | Quinine 3-monooxygenase | Taurochenodeoxycholate 6-alpha-hydroxylase
Type:
Enzyme
Mol. Mass.:
57349.57
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
503
Sequence:
MALIPDLAMETWLLLAVSLVLLYLYGTHSHGLFKKLGIPGPTPLPFLGNILSYHKGFCMFDMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMKSAISIAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYGDVLVRNLRREAETGKPVTLKDVFGAYSMDVITSTSFGVNIDSLNNPQDPFVENTKKLLRFDFLDPFFLSITVFPFLIPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMIDSQNSKETESHKALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEIDAVLPNKAPPTYDTVLQMEYLDMVVNETLRLFPIAMRLERVCKKDVEINGMFIPKGVVVMIPSYALHRDPKYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLSLGGLLQPEKPVVLKVESRDGTVSGA