Reaction Details Report a problem with these data
Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50085768
Substrate
n/a
Meas. Tech.
ChEMBL_71743 (CHEMBL680265)
Ki
0.27±n/a nM
Citation
Rivier, JE; Jiang, G; Struthers, RS; Koerber, SC; Porter, J; Cervini, LA; Kirby, DA; Craig, AG; Rivier, CL Design of potent dicyclic (1-5/4-10) gonadotropin releasing hormone (GnRH) antagonists. J Med Chem 43:807-18 (2000) [PubMed] Article
More Info.:
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR_RAT | GnRH receptor | GnRH-R | Gnrhr
Type:
PROTEIN
Mol. Mass.:
37767.60
Organism:
Rattus norvegicus
Description:
ChEMBL_1335047
Residue:
327
Sequence:
MANNASLEQDQNHCSAINNSIPLTQGKLPTLTLSGKIRVTVTFFLFLLSTAFNASFLVKLQRWTQKRKKGKKLSRMKVLLKHLTLANLLETLIVMPLDGMWNITVQWYAGEFLCKVLSYLKLFSMYAPAFMMVVISLDRSLAVTQPLAVQSKSKLERSMTSLAWILSIVFAGPQLYIFRMIYLADGSGPAVFSQCVTHCSFPQWWHEAFYNFFTFSCLFIIPLLIMLICNAKIIFALTRVLHQDPRKLQLNQSKNNIPRARLRTLKMTVAFGTSFVICWTPYYVLGIWYWFDPEMLNRVSEPVNHFFFLFAFLNPCFDPLIYGYFSL
Inhibitor
Name:
BDBM50085768
Synonyms:
CHEMBL268538 | Gonadotropin Releasing Hormone analogue
Type:
Small organic molecule
Emp. Form.:
C73H87FN16O13
Mol. Mass.:
1415.5697
SMILES:
CC(C)C[C@@H]1NC(=O)[C@H](Cc2ccc3ccccc3c2)NC(=O)[C@H](Cc2ccc(O)cc2)NC(=O)[C@H](CC(=O)NCC(NC(=O)[C@@H]2CCCN2C(=O)[C@H](CCCNC(N)=N)NC1=O)C(N)=O)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(F)cc1)NC(=O)[C@@H]1C=CCN1C(C)=O |c:104|