Reaction Details Report a problem with these data
Target
Growth factor receptor-bound protein 2
Ligand
BDBM50087243
Substrate
n/a
Meas. Tech.
ChEBML_72500
Kd
200±n/a nM
Citation
 Liu, WQ; Vidal, M; Mathé, C; Périgaud, C; Garbay, C Inhibition of the ras-dependent mitogenic pathway by phosphopeptide prodrugs with antiproliferative properties. Bioorg Med Chem Lett 10:669-72 (2000) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50087243
Synonyms:
CHEMBL436789 | Pro-Ser-F2Pmp-Val-Asn-Val-Gln-Asn
Type:
Small organic molecule
Emp. Form.:
C41H62F2N11O16P
Mol. Mass.:
1033.9656
SMILES:
CC(C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(cc1)C(F)(F)P(O)(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O
Structure:
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