Reaction Details Report a problem with these data
Target
Urease subunit alpha [1-30]/beta/gamma
Ligand
BDBM50532143
Substrate
n/a
Meas. Tech.
ChEMBL_1921927 (CHEMBL4424772)
IC50
68990±n/a nM
Citation
 Arshia, na; Begum, F; Almandil, NB; Lodhi, MA; Khan, KM; Hameed, A; Perveen, S Synthesis and urease inhibitory potential of benzophenone sulfonamide hybrid in vitro and in silico. Bioorg Med Chem 27:1009-1022 (2019) [PubMed]  Article 
Target
Name:
Urease subunit alpha [1-30]/beta/gamma
Synonyms:
Bacterial urease
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of ChEMBL is 1921927
Components:
This complex has 3 components.
Component 1
Name:
Urease subunit gamma
Synonyms:
3.5.1.5 | Urea amidohydrolase subunit gamma | Urease subunit gamma | URE3_ECOLX | ureA
Type:
PROTEIN
Mol. Mass.:
10980.28
Organism:
Escherichia coli
Description:
ChEMBL_106183
Residue:
100
Sequence:
MELTPREKDKLLLFTAGLVAERRLARGLKLNYPEAVALISCAIMEGARDGKTVAQLMSEGRTLLTAEQVMEGVPEMIKDIQVECTFPDGTKLVSIHDPIV
  
Component 2
Name:
Urease subunit beta
Synonyms:
3.5.1.5 | Urea amidohydrolase subunit beta | Urease subunit beta | URE2_ECOLX | ureB
Type:
PROTEIN
Mol. Mass.:
11995.91
Organism:
Escherichia coli
Description:
ChEMBL_106183
Residue:
107
Sequence:
MIPGEIKVNHALGDIELNAGRETQTIQVANHGDRPIQIGSHYHFYEVNDALKFERENTLGFRLNIPAGMAVRFEPGQSRTVELVAFSGKREIYGFHGKVMGKLESEN
  
Component 3
Name:
Urease subunit alpha
Synonyms:
3.5.1.5 | URE1_ECOLX | Urea amidohydrolase subunit alpha | ureC
Type:
PROTEIN
Mol. Mass.:
3418.90
Organism:
Escherichia coli
Description:
ChEMBL_106183
Residue:
30
Sequence:
MKTISRQAYADMFGPTTGDRLRLADTELFL
  
Inhibitor
Name:
BDBM50532143
Synonyms:
CHEMBL4555860
Type:
Small organic molecule
Emp. Form.:
C20H17N3O4S
Mol. Mass.:
395.44
SMILES:
[#6]-c1ccc(cc1S(=O)(=O)[#7]\[#7]=[#6](\c1ccccc1)-c1ccccc1)-[#7+](-[#8-])=O
Structure:
Search PDB for entries with ligand similarity: